Treatment Transfers Acid Reflux Issue to High Blood Pressure Problem
In a significant finding, a study conducted at the University of Buffalo - SUNY has revealed a potential association between the long-term use of Proton Pump Inhibitors (PPIs) and new cases of hypertension in menopausal women.
Over a mean follow-up period of 8.7 years, out of 64,720 participants, 28,951 new cases of hypertension were reported. The study suggests that PPIs may increase the risk of developing hypertension due to their effect on nitric oxide production.
Nitric oxide, a natural vasodilator produced by the body, helps relax blood vessels and lower blood pressure. By reducing stomach acid production, PPIs may interfere with the conversion of dietary nitrates into nitric oxide, leading to decreased nitric oxide levels and thus elevated blood pressure.
This connection between PPIs and hypertension has also been observed in other studies. PPIs have been linked to an increased risk of stroke, bone fracture, pneumonia, type 2 diabetes, Clostridium difficile infection, and kidney damage, suggesting that their effects extend beyond acid suppression alone.
However, the relationship between gastroesophageal reflux disease (GERD), which PPIs treat, and hypertension is not clear-cut. Some studies show that hypertension might increase the risk of GERD, while others suggest the reverse.
Despite this, it is important to note that if you develop GERD, the more serious form of acid reflux, you could be at higher risk of developing Barrett’s esophagus, a dangerous condition.
To help control GERD, acid reflux, and heartburn, maintaining a normal weight, not smoking, engaging in moderate to vigorous physical activity for at least 30 minutes a day, and restricting coffee, tea, and sodas to no more than 2 cups per day are recommended. High-fiber foods, such as whole grains, root vegetables, and green vegetables, can curb overeating, which contributes to GERD. Eating foods with a higher pH, such as bananas, melons, cauliflower, fennel, and nuts, can also help offset stomach acid and potentially control acid reflux.
Interestingly, some foods like olive oil, apple cider vinegar, carob, and turmeric are safe remedies for acid reflux. Curcumin, a compound found in turmeric, is just as effective as omeprazole (a common PPI) at relieving the symptoms of indigestion, including acid reflux.
In conclusion, the main proposed mechanism linking PPIs to hypertension is the reduction of nitric oxide due to altered dietary nitrate metabolism caused by acid suppression, which may lead to increased blood vessel constriction and raised blood pressure. While more research is needed to fully understand this association, it is essential for individuals using PPIs to be aware of this potential risk and discuss their medication use with their healthcare provider.
Maintaining optimal health-and-wellness is crucial, especially when considering long-term use of medications like Proton Pump Inhibitors (PPIs). The science behind PPIs suggests they might increase the risk of developing inflammation, such as hypertension, due to their effect on nitric oxide production, a vital component for wellness and fitness-and-exercise. To combat acid reflux disorders like GERD, it's recommended to focus on proper nutrition, including consuming high-fiber foods and certain remedies like olive oil, apple cider vinegar, carob, and turmeric, which may help control symptoms without contributing to potential hypertension.
