Magdeburg Chemists Achieve Breakthrough in Cancer Research with Disorazol Z1 Synthesis
Chemists at the University of Magdeburg have made a significant breakthrough in cancer research. They have successfully synthesized Disorazol Z1, a highly active natural substance with potent anti-cancer properties. The team, led by Prof. Dr. Dieter Schinzer, plans to patent and publish their discovery, and explore its medical applicability and industrial production.
Disorazol Z1 is produced by myxobacteria found in organic waste like goat manure. The team faced a significant challenge in synthesizing this compound, requiring innovative strategies and modern chemical techniques. Despite the hurdles, they successfully achieved the first total synthesis of Disorazol Z1.
The substance has shown remarkable cytotoxicity, preventing cell division and destroying cancer cells. The team's goal is to adapt the molecule to dock with a specific protein, guiding it to tumors and selectively inhibiting tumor cell division. To this end, they plan to collaborate with pharmaceutical companies specializing in oncology drug development, although specific names are not disclosed. The chemical synthesis of Disorazol Z1 allows for specific modification and optimization of the compound for medical applications.
The project was funded by state funds and the European Fund for Regional Development (EFRE), with a total volume of around 1.7 million euros.
This discovery could pave the way for new cancer treatments. The team's next steps include further investigating the medical applicability and industrial production of Disorazol Z1. With the support of their industrial partners, they aim to bring this promising compound closer to clinical use.
