Cost, implications, applications, dosage guidelines, and additional information on Voranigo
Unleashing Voranigo:
Voranigo, a brand-name drug, is utilized to treat specific brain tumors. This medication contains the active ingredient vorasidenib, a type of targeted cancer therapy.
The Food and Drug Administration (FDA) has given approval for Voranigo to treat grade 2 astrocytomas and oligodendrogliomas in both adults and children aged 12 years and over. In certain circumstances, it is used to manage these brain tumors. To learn more about Voranigo's purpose, head to the "Voranigo use" section.
Drug specifics:- Drug category: Voranigo falls under isocitrate dehydrogenase-1 and isocitrate dehydrogenase-2 inhibitor, a specific kind of targeted cancer therapy.- Generic availability: Unfortunately, no generic version of Voranigo is currently offered.- Prescription required: Yes, a prescription is necessary to obtain Voranigo.- Controlled substance: No, Voranigo is not a controlled substance.
Voranigo generic
Voranigo is exclusively obtainable as a brand-name medication at the moment. It's not currently available in generic form.
A generic drug typically offers the exact same active ingredient as a brand-name medication, often at a lower cost.
Voranigo cost and coupons
The cost of Voranigo can vary depending on your insurance coverage, location, and pharmacy. To save on the cost of your medication, visit the ServierONE program or contact them at 800-813-5905 for more information and potential financial aid.
Voranigo side effects
Mild or severe side effects can arise while using Voranigo. Here are some of the common side effects:
- Fatigue
- headache
- nausea
- diarrhea
- constipation
- decreased appetite
- muscle and joint pain
- COVID-19
- decreased white blood cell count
- increased liver enzymes
Most of these side effects tend to vanish within a few days to a couple of weeks. However, if they become more severe or persist, consult your doctor or pharmacist.
Serious side effects:
Severe side effects from Voranigo are not common, but they can occur. Seek medical attention immediately if you have serious side effects. Dial 911 or your local emergency phone number if symptoms feel life-threatening.
Seizures
Seizures may be a severe side effect, with symptoms like staring into space, rapid blinking, sudden stiffening of the arms and body, jerking body movements, and loss of consciousness.
Liver problems
Signs of possible liver problems can include:- pain in the upper right abdomen- loss of appetite- exhaustion- dark urine- jaundice
ALLERGIC REACTION
Though not reported in the drug's studies, some people may experience an allergic reaction to Voranigo. Symptoms of an allergic reaction can be mild or severe.
Ways to manage:For mild allergic reaction symptoms, such as a rash, contact your doctor immediately. They may suggest treatments to manage your symptoms. If you have a severe allergic reaction, call 911 or your local emergency number right away. If you've had a life-threatening allergic reaction to Voranigo, your doctor may recommend alternative medication instead.
Voranigo uses
Voranigo for certain brain tumors
Voranigo is FDA-approved to treat specific brain tumors named astrocytomas and oligodendrogliomas.
These brain tumors belong to a group of tumors called gliomas. Astrocytomas start in brain cells called astrocytes, while oligodendrogliomas begin in brain cells called oligodendrocytes.
less than 40 kg (about 88 pounds [lb])
Voranigo is prescribed to treat these brain tumors if they have a specific genetic mutation (an abnormal change in a gene). Before prescribing Voranigo, your doctor will likely carry out a biopsy to examine whether the cells from the tumor have this mutation.
If you experience symptoms like:- severe headaches, especially in the morning- nausea and vomiting- vision, hearing, or speech problems- balance issues- weakness or numbness on one side of the body- personality or behavioral changes- seizures
Voranigo may help stop your brain tumor from growing and getting worse. It is used after undergoing a biopsy or surgery to remove part or all of the tumor.
Voranigo and children
Voranigo is FDA-approved for children aged 12 years and older to treat astrocytomas and oligodendrogliomas.
20 mg once per day
Voranigo has not been tested on children younger than 12 years old. It is not known whether it is safe or effective in this age group.
Voranigo dosage:
The dosage your doctor prescribes will be based on factors like your age, weight, and whether you have certain side effects while taking Voranigo. Here is the typical Voranigo dosage recommendation in various forms and strengths:- Tablet (oral): 10 milligrams (mg) and 40 mg.
Dosage for certain brain tumors:
In adults, the typical recommended dosage is 40 mg once daily.
For children aged 12 years and older, dosage depends on their weight:
- Less than 40 kg (about 88 pounds [lb]): 20 mg once daily.
- 40 kg or more: 40 mg once daily.
Taking Voranigo:
Some key points about Voranigo dosing:
- You should take Voranigo once daily. Try taking the medication at the same time every day.
- If you miss a dose and it's been 6 hours or less since the dose was due, take the missed dose as soon as possible. Then take your next dose at your usual time. If more than 6 hours have passed, skip the missed dose and take the next dose at your usual time. Never take double doses or extra doses to make up for missed doses.
- You can take Voranigo with or without food.
- Do not crush, split, or chew Voranigo tablets. If you struggle with swallowing the tablets, discuss this issue with your doctor or pharmacist.
- Voranigo is intended for long-term use. Consult your doctor for determining the best dosage for you.
- Voranigo works gradually. You might not notice it working. The medication slows the growth of the brain tumor and hinders it from getting worse.
40 kg or more
Overdose:
To prevent unwanted side effects or overdose, do not take more Voranigo than your doctor recommends.
What to do in case of overdose:
If you suspect an overdose, contact your doctor immediately. Additionally, contact America's Poison Centers at 800-222-1222 or use its online tool. If your symptoms are severe, call 911 or your local emergency number or go to the nearest emergency department right away.
Voranigo interactions
40 mg once per day
Voranigo can cause negative interactions when combined with certain medications, supplements, and foods. Consult your doctor and pharmacist about any drugs, vitamins, herbs, and supplements you are taking before starting Voranigo.
Medications that may interact with Voranigo:
- ciprofloxacin (Cipro)
- cyclosporine
- fluvoxamine (Luvox)
- phenytoin (Dilantin, Phenytek)
- rifampin (Rifadin, Rimatane)
- hormonal forms of birth control, including combined pill, minipill, or patch
Alcohol Interaction
It may not be safe to consume alcohol while taking Voranigo. Alcohol and Voranigo can cause similar side effects, such as headache, nausea, diarrhea, and liver problems. If you have questions about drinking alcohol while taking Voranigo, consult your doctor or pharmacist.
Alternatives to Voranigo
Other brain tumor treatments exist, such as:
- Chemotherapy with drugs such as:
- PCV combination regimen (procarbazine, lomustine [CCNU], and vincristine)
- temozolomide
- Radiation therapy
If you're interested in finding an alternative to Voranigo, discuss your options with your doctor.
Things to consider when taking Voranigo:
Voranigo and Pregnancy:
Voranigo can cause harm to a fetus and should not typically be taken during pregnancy. If you're pregnant, discuss your treatment options with your doctor.
Voranigo and Fertility:
Voranigo can reduce fertility in both males and females who take the medication. If you want to conceive in the future, consult your doctor about your options before starting Voranigo treatment.
Voranigo and Breastfeeding:
Voranigo should not be taken while breastfeeding. If you're currently breastfeeding or planning to do so, consult your doctor before taking this medication. Your doctor may suggest a different treatment for your condition or recommend other ways to feed a baby who is breastfed.
How Voranigo works
Voranigo is used to treat specific brain tumors called grade 2 astrocytomas and oligodendrogliomas. It is effective for tumors of this type that have a specific genetic mutation.
A genetic mutation is an abnormal change in a gene. A gene is a piece of DNA that carries instructions for making particular proteins. When a cell has a mutated gene, it causes the cells to make abnormal versions of a particular protein.
Voranigo works by blocking the action of abnormal IDH1 and IDH2 enzymes in brain tumor cells. This slows down the growth of the tumor cells, which helps stop the brain tumor from growing and getting worse.
• ciprofloxacin (Cipro)• cyclosporine (Neoral, others)• fluvoxamine (Luvox)• phenytoin (Dilantin, Phenytek)• rifampin (Rifadin, Rimatane)• hormonal forms of birth control, such as the combined pill, minipill, or patch
[1] https://www.govinfo.gov/content/pkg/PLAW-114publ197/html/PLAW-114publ197.htm
[2] https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/215459s000lbl.pdf
[3] https://www.accessdata.fda.gov/scripts/cder/obamacare/index.cfm?cid=32&id=3394
- Voranigo, a drug for specific brain tumors, contains the active ingredient vorasidenib, a type of targeted cancer therapy.
- To learn more about Voranigo's purpose in treating grade 2 astrocytomas and oligodendrogliomas, visit the "Voranigo use" section.
- A generic drug, offering the same active ingredient as a brand-name medication, can often be at a lower cost, but currently, there is no generic version of Voranigo available.
- Seizures may be a severe side effect of Voranigo, with symptoms like staring into space, sudden stiffening, and loss of consciousness, especially in children weighing less than 40 kg.
- If a life-threatening allergic reaction to Voranigo occurs, your doctor may recommend alternative medication instead.
