Connection Between Breast and Ovarian Cancer: Identified Factors and Linkages
In the ballpark: Breast cancer and ovarian cancer share a strong link, primarily due to shared genetic factors, especially the BRCA1 and BRCA2 genes. This connection means individuals carrying these mutations have a higher risk of developing both cancers.
Beyond these genes, family history, reproductive factors, genetic factors, hormonal influences, and lifestyle habits also play significant roles in the development of both cancers. People with a family history of breast or ovarian cancer or those with increased reproductive age, fewer children, or a history of never giving birth have higher risks.
Other genetic mutations beyond BRCA1/2, homologous recombination deficiency, and hormonal factors such as hormone replacement therapy contribute to the risks. Lifestyle factors like obesity and alcohol consumption, while more commonly linked to breast cancer, can also affect overall risk.
If you've had breast or ovarian cancer, it's crucial to work closely with your healthcare provider to monitor for signs of another cancer. People with a history of these cancers should undergo regular screening, which may include mammograms, breast MRI scans, pelvic exams, transvaginal ultrasounds, and CA-125 blood tests. Genetic testing for BRCA1, BRCA2, and other relevant mutations can help determine effective strategies for monitoring and prevention.
For those carrying genetic mutations, doctors may consider additional options like prophylactic surgeries to prevent cancer occurrence or spread. Modifiable risk factors like achieving and maintaining a moderate weight, regular exercise, reducing alcohol intake, and discussing contraception options with a doctor can reduce the risk of both cancers.
Individuals with a higher risk of ovarian cancer include those with BRCA1 or BRCA2 gene mutations, a family history of ovarian, breast, or colorectal cancer, Lynch syndrome, endometriosis, never having been pregnant, having a late first pregnancy, or being over 40 years old.
If you're concerned about your breast or ovarian cancer risk or want more information, speak with your healthcare team. For more evidence-based information and resources related to cancer, visit our dedicated hub.
- The link between breast cancer and ovarian cancer is primarily due to shared genetic factors, such as the BRCA1 and BRCA2 genes.
- Family history, reproductive factors, and hormonal influences also play significant roles in the development of both cancers.
- Lifestyle habits, including obesity and alcohol consumption, can affect the overall risk of both breast and ovarian cancer.
- If you've had breast or ovarian cancer, it's crucial to work closely with your healthcare provider to monitor for signs of another cancer.
- Genetic testing for BRCA1, BRCA2, and other relevant mutations can help determine effective strategies for monitoring and prevention.
- Individuals with a higher risk of ovarian cancer include those with BRCA1 or BRCA2 gene mutations, a family history of ovarian, breast, or colorectal cancer, Lynch syndrome, endometriosis, never having been pregnant, having a late first pregnancy, or being over 40 years old.
